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RCN Arthroclem '8' 60 Capsules

$24.90


ARTHROCLEM 

Supporting Healthy Joints

The 8 ingredients have synergistic action and are well documented in the literature to support health joints. The amount of Glucosamine and Chondroitin has been carefuly selected to reduce the risk of digestive discomfort without jeopardizing the effectiveness. Arthroclem 8 is extremely well tolerated.

60 capsules per container. One capsule two to three times daily with meals. Shuster certified (Manufacturers of dietary supplements who can meet the program's quality criteria will receive the prestigious Shuster 'Seal of Quality') The Shuster seal assures-to the consumer- That the product has achieved a high quality standard. Manufactured in a FDA inspected facility. Since the introduction of Arthroclem in 2002 we had no adverse events or side-effect reported.  

  1. Glucosamine 300 mg - GLUCOSAMINE SULFATE is a supplement used in osteoarthritis.
    When orally given, it is more effective than placebo and at least as effective as non-steroidal anti-inflammatory drugs in relieving osteoarthritis symptoms.
  2. Chondroitine Sulfate 200 mg - Chondroitin also inhibits leukocyte protease, thus reducing white blood cells (leukocytes) activity in the joint. Leukocyte protease allows white blood cell to destroy wounded tissues to allow for better healing. Once again, white blood cells have a necessary effect to fight off intruders (bacteria, foreign bodies). But in the case of chronic inflammation, the immune system starts fighting its own body (autoimmune disease) and damages the tissues it is supposed to protect. CHONDROITINE reduces inflammation.This effect is explained by many action mechanisms. First, it causes a decline in pro-inflammation prostaglandins. Then, it inhibits many enzymes secreted by chondrocytes: elastase and hyaluronidase. These enzymes are responsible for the elimination of old cartilage, making room for the new one. It is a useful and desirable effect in healthy cartilage but becomes out of control in wounded or inflamed joint.
  3. MSM 200 mg - MSM a Sulfur compound. Sulfur is one of the basic elements of life.In fact, sulfur is the fourth most abundant mineral in the body. The proper acid alkaline balance of the body cannot be maintained without it. MSM can lower your pain levels by 50% or more, MSM reduces inflammation and helps to restore your mobility. Sulfur is vital to the creation and regeneration of the body's tissues. Sulfur is an indispensable component in human nutrition. MSM is found in every cell in the body. Sulfur itself is held mainly in the muscles, skin, bones, nails and hair.MSM provides the essential sulfur necessary for a number of body compounds. Veterinarians became interested in MSM and found that it worked on pets suffering from arthritis and lameness.MSM can help produce a solid base energy and at the same time it helps a person to be calm. MSM supplementation can help the body replace damaged cells with good healthy elastic cells.MSM is found in raw fruits, vegetables, nuts, and seeds. MSM is destroyed by cooking, and is extremely water soluble.MSM evaporates quickly, and is destroyed during storage. MSM is sulfur and sulfur is found in eggs, cheese, and meats.A deficiency in sulfur may cause slow growth or fatigue.The human body requires 400 mg to 800 mg of dietary organic sulphur daily. Little is known about the exact amounts that animals require in their diet but it is practically impossible to give an overdose of sulphur.After ingestion MSM stays in the blood for much longer than other organic sulphur molecules.
  4. Chicken Collagen Type II 100 mg - CHICKEN COLLAGEN Several controlled trial provides evidence that oral administration of small quantities of solubilized native heterologous type II collagen is both safe and can improve the clinical manifestations of active rheumatoid arthritis. The Harvard Medical School study found that several of the joint sufferers taking daily Type II Collagen from chicken cartilage were able to successfully decrease or, in some cases, eliminate joint medication.
  5. Flaxseed 100 mg - ORGANIC FLAXSEED is derived from the flax plant. The seeds and oil of the flax plant also contain substances that promote good health.Flaxseed and flaxseed oil are rich in alpha-linolenic acid (ALA), an essential fatty acid that appears to be beneficial for heart disease, inflammatory bowel disease, arthritis, and a variety of other health problems. ALA belongs to a group of substances called omega-3 fatty acids.

    It is important to maintain an appropriate balance of omega-3 and omega-6 (another essential fatty acid) in the diet as these two substances work together to promote health. Omega-3 fatty acids help reduce inflammation and most omega-6 fatty acids tend to promote inflammation.An inappropriate balance of these essential fatty acids contributes to the development of disease while a proper balance helps maintain and even improve health. A healthy diet should consist of roughly two to four times more omega-6 fatty acids than omega-3 fatty acids.The typical American diet tends to contain 14 to 30 times more omega-6 fatty acids than omega-3 fatty acids and many researchers believe this imbalance is a significant factor in the rising rate of inflammatory disorders in the United States.

    Studies suggest that flaxseed (both the ALA and the lignans in flaxseed) may play a role in the prevention and/or treatment of Arthritis Several studies suggest that omega-3 fatty acids reduce tenderness in joints, decrease morning stiffness, improve mobility, and allow for a reduction in the amount of medication needed for people with rheumatoid arthritis and, probably, osteoarthritis as well.Lignans from Flaxseed

    In addition to the important omega-3 fatty acid ALA as outlined. flaxseed also contains a group of chemicals called lignans that may play a role in the prevention of cancer.Lignans are plant compounds that mimic the action of the hormone estrogen. For this reason, lignans are considered phyto (plant) estrogens.

  6. Bromelain 30 mg  - BROMELAIN is a general name for a family of sulfhydryl-containing, proteolytic enzymes obtained from Ananas comosus, the pineapple plant. Bromelain's primary component is a sulfhydryl proteolytic fraction. Bromelain also contains a peroxidase, acid phosphatase, several protease inhibitors, and organically-bound calcium. It appears a great deal of the physiological activity of bromelain cannot be accounted for by its proteolytic fraction and that the beneficial effects of bromelain are due to multiple factors, not to one single, isolated factor.

    Pharmacokinetics Bromelain is absorbed intact through the gastrointestinal tract of animals, with up to 40 percent of the high molecular weight substances detected in the blood after oral administration.1 Mechanisms of Action Bromelain's anti-inflammatory activity appears to be due to a variety of physiological actions. Evidence indicates that bromelain's action is in part a result of inhibiting the generation of bradykinin at the inflammatory site via depletion of the plasma kallikrein system, as well as limiting the formation of fibrin by reduction of clotting cascade intermediates.Bromelain has also been shown to stimulate the conversion of plasminogen to plasmin, resulting in increased fibrinolysis.Bromelain might be capable of selectively modulating the biosynthesis of thromboxanes and prostacyclins, two groups of prostaglandins with opposite actions which ultimately influence activation of cyclic-3,5-adenosine, an important cell-growth modulating compound.It is hypothesized that bromelain therapy leads to a relative increase of the endogenous prostaglandins, PGI2 and PGE2 over thromboxane A2.5 BROMELAIN has been shown to decrease aggregation of blood platelets.It is an effective fibrinolytic agent in vitro and in vivo; however, its effect is more evident in purified fibrinogen solutions than in plasma.Bromelain's most common application is in the treatment of inflammation.

    Toxicity, Side Effects and Allergic Reactions Bromelain is considered to have very low toxicity, with an LD50 greater than 10g/kg.Toxicity tests on dogs, with increasing levels of bromelain up to 750 mg/kg administered daily, showed no toxic effects after six months. Dosages of 1.5 g/kg/day administered to rats showed no carcinogenic or teratogenic effects.There is a possibility of allergy with all proteolytic enzymes

  7. Boswellia 10 mg  - BOSWELIA (active ingredient - terpenoids): Boswelia has been used to treat osteoarthritis. Boswelia behaves much like other NSAID's (i.e. Aspirin, Motrin, Celebrex) in that it decreases inflammation. It does so by decreasing the number of leukotrienes, one of the molecules responsible for causing inflammation. Boswelia has the benefit of producing little or no irritation or ulceration of the stomach.Side effects are generally rare and may include diarrhea, skin rash, and nausea.
  8. Curcumin 10 mg  - CURCUMIN Turmeric (Curcuma Longa)is a spice from Asia, in the ginger family. It is mainly used in curries and as a yellow coloring agent in food.
    The active ingredients are curcumino?ds, mostly curcumin (diferuloylmethane). A staple of Ayurvedic medicine for inflammation and osteoarthritis, it has been used for thousands of years.

    The anti-inflammatory property may be due to its effect on the e?cosano?d biosynthesis and the arachidonic acid pathway enzymes.Muscle regeneration Curcumin suppresses a factor that influences growth factors. This factor, NF B (nuclear factor kappa B), plays a prominent role in immunity and cell growth. Immediately after muscle injury, the immune system dispatches cells to the area. Their job is to destroy old tissue and begin new construction. NF B is one of the lines of communication immune cells use to get things done. By influencing NF B, curcumin modulates the repair process.The regeneration of muscle is a complex phenomenon. Curcumin works in part by adjusting the arrival time and status of chemical messengers known as cytokines. Cytokines appear at the scene early on, and they have a powerful effect on inflammation and cell growth.

    A cytokine known as IL-6 (interleukin-6), for example, makes muscle cells multiply. Another one called TNF (tumor necrosis factor) keeps cells from growing up, developing. By suppressing one, and enhancing the other, curcumin can speed things up.

    The authors of a study published in 1999 think that curcumin works by other mechanisms that probably involve growth factors, but this has not been proven yet. In other attempts to make muscles regenerate, researchers have tried injecting synthetic growth factors or transplanting myoblasts?all with limited success.

    Curcumin seems to be a much safer, more effective treatment?at least in the early stages. The effects of curcumin are felt early on?right after injury when the body first sends out the repair squads. So if you want to try curcumin for muscle regeneration, make sure you take it as soon as the injury occurs.

    The authors of the study predict that curcumin may be useful not only for accidental injuries or sports, but also to help repair surgical damage. Thaloor D, et al. 1999. Systemic administration of the NF- B inhibitor curcumin stimulates muscle regeneration after traumatic injury. Am J Physiol 277(2 pt 1):C320-29.Improve collagen status and tissue regenerationWound treatment may be enhanced by curcumin, it turns out.

    In an experiment using groups of curcumin-treated and untreated rats and guinea pigs, researchers discovered ?faster wound closure? in the treated animals compared to their untreated counterparts. Subsequent biopsies of the wounds showed redevelopment of epidermal cells, increased migration of various other cells to the wound site like myofibroblasts, fibroblasts and macrophages, and extensive re-growth of blood vessels.

    As a follow-up to a study, scientists reached similar results among diabetic rodents who experienced impaired healing. The researchers found improved blood vessel formation, increased cell migration to the wound site, and higher levels of collagen, a fibrous protein found in connective tissue, bone and cartilage.

    Sidhu GS et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen 1998 Mar-Apr;6(2):167-77.Sidhu GS et al. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen 1999 Sep-Oct;7(5):362-74.

References

White RR, Crawley FE, Vellini M, et al. Bioavailability of 125I bromelain after oral administration to rats. Biopharm Drug Dispos 1988;9:397-403.
Kumakura S, Yamashita M, Tsurufuji S. Effect of bromelain on kaolin-induced inflammation in rats. Eur J Pharmacol 1988;150:295-301.
Uchida Y, Katori M. Independent consumption of high and low molecular weight kininogens in vivo. Adv Exp Med Biol 1986;198:113-118.
Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.
Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses 1980;6:1123-1133.6. Heinicke RM, Van der Wal M, Yokoyama MM. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-845.
De-Giuli M, Pirotta F. Bromelain: interaction with some protease inhibitors and rabbit specific antiserum. 8 Drugs ExpClin Res 1978;4:21-23.
Taussig SJ, Yokoyama MM, Chinen N, et al. Bromelain: A proteolytic enzyme and its clinical application. Hiroshima J Med Sci 1975;24:185-193.

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